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KMID : 1134820070360080983
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 8 p.983 ~ p.988
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Effect of Epigallocatechin Gallate on Inhibition of Cell Proliferation in MDA-MB-231 Human Breast Cancer Cells
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Hong Eun-Jung
Kim Woo-Kyung
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Abstract
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Epigallocatechin gallate (EGCG), a principal antioxidant derived from green tea, is one of the most extensively investigated chemopreventive phytochemicals. However, the effect of EGCG on proliferation in MDA?MB?231 breast cancer cell is not well known. We investigated the effect of EGCG on protein and mRNA expression related to cell proliferation in MDA?MB?231 human breast cancer cell lines. We cultured MDA?MB ?231 cells in the presence of 0, 5, 10 and 20 ㎛ of EGCG. EGCG significantly inhibited the cancer cell proliferation (p＜0.05). In MDA?MB?231 huamn breast cancer cell, EGCG lowered ErbB₂ and ErbB₃ protein as well as mRNA expression. In addition, protein and mRNA expression of phosphorylated Akt and total Akt were significantly decreased (p＜0.05). We suggest that EGCG inhibits cell proliferation through ErbB₂, ErbB₃ and Akt cell signaling.
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KEYWORD
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epigallocatechin gallate, breast cancer, ErbB₂, ErbB₃, Akt
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